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Members of the PIAS family act as SUMO ligases for c-Jun and p53 and repress p53 activity
The activity of the p53 tumor suppressor protein and the c-Jun protooncogene is regulated by posttranslational modifications, such as phosphorylation or ubiquitination. In addition, covalent attachment of the ubiquitin-like modifier SUMO appears to modulate their transcriptional activity. Sumoylatio...
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| Huvudupphovsmän: | , |
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| Materialtyp: | Artigo |
| Språk: | Inglês |
| Publicerad: |
The National Academy of Sciences
2002
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| Ämnen: | |
| Länkar: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122440/ https://ncbi.nlm.nih.gov/pubmed/11867732 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052559499 |
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