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Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate

Presenilin heterodimers apparently contain the active site of γ-secretase, a polytopic aspartyl protease involved in the transmembrane processing of both the Notch receptor and the amyloid-β precursor protein. Although critical to embryonic development and the pathogenesis of Alzheimer's disease, th...

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I publikationen:Proc Natl Acad Sci U S A
Huvudupphov: Esler, William P., Kimberly, W. Taylor, Ostaszewski, Beth L., Ye, Wenjuan, Diehl, Thekla S., Selkoe, Dennis J., Wolfe, Michael S.
Materialtyp: Artigo
Språk:Inglês
Utgiven: National Academy of Sciences 2002
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122414/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11867728/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052436599
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