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Activity-dependent isolation of the presenilin– γ-secretase complex reveals nicastrin and a γ substrate
Presenilin heterodimers apparently contain the active site of γ-secretase, a polytopic aspartyl protease involved in the transmembrane processing of both the Notch receptor and the amyloid-β precursor protein. Although critical to embryonic development and the pathogenesis of Alzheimer's diseas...
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| Autori principali: | , , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The National Academy of Sciences
2002
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122414/ https://ncbi.nlm.nih.gov/pubmed/11867728 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052436599 |
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