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Identification of furin pro-region determinants involved in folding and activation.
The pro-region of the subtilisin-like convertase furin acts early in the biosynthetic pathway as an intramolecular chaperone to enable proper folding of the zymogen, and later on as an inhibitor to constrain the activity of the enzyme until it reaches the trans -Golgi network. To identify residues t...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2004
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1224113/ https://ncbi.nlm.nih.gov/pubmed/14741044 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031902 |
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