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Stability of mutant serpin/furin complexes: Dependence on pH and regulation at the deacylation step
Furin proteolytically cleaves a wide variety of proprotein substrates mainly within the trans-Golgi network (TGN) but also at the cell membrane and in endosomal compartments where pH is more acidic. Incorporation of furin recognition sequences within the reactive site loop (RSL) of α(1)-antitrypsin...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2253415/ https://ncbi.nlm.nih.gov/pubmed/15659365 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.04843305 |
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