Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands

Telomeres of human chromosomes contain a G-rich 3′-overhang that adopts an intramolecular G-quadruplex structure in vitro which blocks the catalytic reaction of telomerase. Agents that stabilize G-quadruplexes have the potential to interfere with telomere replication by blocking the elongation step...

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Main Authors: Riou, J. F., Guittat, L., Mailliet, P., Laoui, A., Renou, E., Petitgenet, O., Mégnin-Chanet, F., Hélène, C., Mergny, J. L.
Format: Artigo
Sprog:Inglês
Udgivet: The National Academy of Sciences 2002
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC122406/
https://ncbi.nlm.nih.gov/pubmed/11854467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052698099
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