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Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
Telomeres of human chromosomes contain a G-rich 3′-overhang that adopts an intramolecular G-quadruplex structure in vitro which blocks the catalytic reaction of telomerase. Agents that stabilize G-quadruplexes have the potential to interfere with telomere replication by blocking the elongation step...
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| Main Authors: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122406/ https://ncbi.nlm.nih.gov/pubmed/11854467 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052698099 |
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