Cell senescence and telomere shortening induced by a new series of specific G-quadruplex DNA ligands
Telomeres of human chromosomes contain a G-rich 3′-overhang that adopts an intramolecular G-quadruplex structure in vitro which blocks the catalytic reaction of telomerase. Agents that stabilize G-quadruplexes have the potential to interfere with telomere replication by blocking the elongation step...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
2002
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122406/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11854467/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052698099 |
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