Over-expression of sterol-regulatory-element-binding protein-1c (SREBP1c) in rat pancreatic islets induces lipogenesis and decreases glucose-stimulated insulin release: modulation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR).

Accumulation of intracellular lipid by pancreatic islet beta-cells has been proposed to inhibit normal glucose-regulated insulin secretion ('glucolipotoxicity'). In the present study, we determine whether over-expression in rat islets of the lipogenic transcription factor SREBP1c (sterol-r...

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Hlavní autoři: Diraison, Frédérique, Parton, Laura, Ferré, Pascal, Foufelle, Fabienne, Briscoe, Celia P, Leclerc, Isabelle, Rutter, Guy A
Médium: Artigo
Jazyk:Inglês
Vydáno: 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1224038/
https://ncbi.nlm.nih.gov/pubmed/14690455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031277
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