A cofactor approach to copper-dependent catalytic antibodies

A strategy for the preparation of semisynthetic copper(II)-based catalytic metalloproteins is described in which a metal-binding bis-imidazole cofactor is incorporated into the combining site of the aldolase antibody 38C2. Antibody 38C2 features a large hydrophobic-combining site pocket with a highl...

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izdano v:	Proc Natl Acad Sci U S A
Principais autores:	Nicholas, Kenneth M., Wentworth, Paul, Harwig, Curtis W., Wentworth, Anita D., Shafton, Asher, Janda, Kim D.
Format:	Artigo
Jezik:	Inglês
Izdano:	National Academy of Sciences 2002
Teme:	Biological Sciences
Online dostop:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122402/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11880619/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.052001099
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