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A cofactor approach to copper-dependent catalytic antibodies
A strategy for the preparation of semisynthetic copper(II)-based catalytic metalloproteins is described in which a metal-binding bis-imidazole cofactor is incorporated into the combining site of the aldolase antibody 38C2. Antibody 38C2 features a large hydrophobic-combining site pocket with a highl...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122402/ https://ncbi.nlm.nih.gov/pubmed/11880619 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.052001099 |
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