An activating mutant of Rac1 that fails to interact with Rho GDP-dissociation inhibitor stimulates membrane ruffling in mammalian cells.

Rac1, a member of the Rho family of small GTP-binding proteins, is involved in the regulation of the actin cytoskeleton via activation of lamellipodia and membrane ruffle formation. RhoGDI (Rho-family-specific GDP-dissociation inhibitor) forms a complex with Rho proteins in the cytosol of mammalian...

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Autori principali: Gandhi, Payal N, Gibson, Richard M, Tong, Xiaofeng, Miyoshi, Jun, Takai, Yoshimi, Konieczkowski, Martha, Sedor, John R, Wilson-Delfosse, Amy L
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223982/
https://ncbi.nlm.nih.gov/pubmed/14629200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030979
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