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Stimulated initiation of mitogen-activated protein kinase phosphatase-1 (MKP-1) gene transcription involves the synergistic action of multiple cis-acting elements in the proximal promoter.

Mitogen-activated protein kinases (MAPKs) are inactivated by a dual specificity phosphatase, MAPK phosphatase-1 (MKP-1). MKP-1 is transcribed as an immediate early response gene (IEG) following various stimuli. In the pituitary cell line GH4C1, MKP-1 gene transcription is strongly induced by thyrotr...

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Main Authors: Ryser, Stephan, Massiha, Abbas, Piuz, Isabelle, Schlegel, Werner
格式: Artigo
語言:Inglês
出版: 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223957/
https://ncbi.nlm.nih.gov/pubmed/14609431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031022
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