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Up-Regulation of P-TEFb by the MEK1-Extracellular Signal-Regulated Kinase Signaling Pathway Contributes to Stimulated Transcription Elongation of Immediate Early Genes in Neuroendocrine Cells

The positive elongation factor P-TEFb appears to function as a crucial C-terminal-domain (CTD) kinase for RNA polymerase II (Pol II) transcribing immediate early genes (IEGs) in neuroendocrine GH4C1 cells. Chromatin immunoprecipitation indicated that in resting cells Pol II occupied the promoter-pro...

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Bibliografiske detaljer
Main Authors: Fujita, Toshitsugu, Ryser, Stephan, Piuz, Isabelle, Schlegel, Werner
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2258797/
https://ncbi.nlm.nih.gov/pubmed/18086894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01767-07
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