Bax-induced cytochrome c release from mitochondria depends on alpha-helices-5 and -6.

The pro-apoptotic protein Bax plays a key role in the mitochondrial signalling pathway. Upon induction of apoptosis, Bax undergoes a conformational change and translocates to mitochondrial membranes, where it inserts and mediates the release of cytochrome c from the intermembrane space into the cyto...

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Autori principali: Heimlich, Gerd, McKinnon, Alastair D, Bernardo, Katussevani, Brdiczka, Dieter, Reed, John C, Kain, Renate, Krönke, Martin, Jürgensmeier, Juliane M
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223939/
https://ncbi.nlm.nih.gov/pubmed/14614769
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031152
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