Structural and functional dissection of a conserved destabilizing element of cyclo-oxygenase-2 mRNA: evidence against the involvement of AUF-1 [AU-rich element/poly(U)-binding/degradation factor-1], AUF-2, tristetraprolin, HuR (Hu antigen R) or FBP1 (far-upstream-sequence-element-binding protein 1).

COX-2 (cyclo-oxygenase-2) mRNA is degraded rapidly in resting cells, but is stabilized by the mitogen-activated protein kinase p38 signalling pathway in response to pro-inflammatory stimuli. A conserved ARE (AU-rich element) of the COX-2 3' untranslated region, CR1 (conserved region 1), acts as...

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Detalhes bibliográficos
Main Authors: Sully, Gareth, Dean, Jonathan L E, Wait, Robin, Rawlinson, Lesley, Santalucia, Tomas, Saklatvala, Jeremy, Clark, Andrew R
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223914/
https://ncbi.nlm.nih.gov/pubmed/14594446
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031484
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