Catalytic- and ecto-domains of membrane type 1-matrix metalloproteinase have similar inhibition profiles but distinct endopeptidase activities.

Membrane type 1-matrix metalloproteinase (MT1-MMP/MMP-14) is a major collagenolytic enzyme that plays a vital role in development and morphogenesis. To elucidate further the structure-function relationship between the human MT1-MMP active site and the influence of the haemopexin domain on catalysis,...

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Detalhes bibliográficos
Main Authors: Hurst, Douglas R, Schwartz, Martin A, Ghaffari, Mohammad A, Jin, Yonghao, Tschesche, Harald, Fields, Gregg B, Sang, Qing-Xiang Amy
Formato: Artigo
Idioma:Inglês
Publicado em: 2004
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223890/
https://ncbi.nlm.nih.gov/pubmed/14533979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031067
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