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New strategies for targeting matrix metalloproteinases

The development of matrix metalloproteinase (MMP) inhibitors has often been frustrated by a lack of specificity and subsequent off-target effects. More recently, inhibitor design has considered secondary binding sites (exosites) to improve specificity. Small molecules and peptides have been develope...

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Bibliografiske detaljer
Udgivet i:Matrix Biol
Hovedforfatter: Fields, Gregg B.
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4466128/
https://ncbi.nlm.nih.gov/pubmed/25595836
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.matbio.2015.01.002
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