Characterization of a pseudoachondroplasia-associated mutation (His587-->Arg) in the C-terminal, collagen-binding domain of cartilage oligomeric matrix protein (COMP).

We have introduced a pseudoachondroplasia-associated mutation (His(587)-->Arg) into the C-terminal collagen-binding domain of COMP (cartilage oligomeric matrix protein) and recombinantly expressed the full-length protein as well as truncated fragments in HEK-293 cells. CD spectroscopy revealed on...

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Bibliographic Details
Main Authors: Spitznagel, Luitgard, Nitsche, D Patric, Paulsson, Mats, Maurer, Patrik, Zaucke, Frank
Format: Artigo
Language:Inglês
Published: 2004
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223886/
https://ncbi.nlm.nih.gov/pubmed/14580238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031179
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