Embryonic stem cells develop into functional dopaminergic neurons after transplantation in a Parkinson rat model

Although implantation of fetal dopamine (DA) neurons can reduce parkinsonism in patients, current methods are rudimentary, and a reliable donor cell source is lacking. We show that transplanting low doses of undifferentiated mouse embryonic stem (ES) cells into the rat striatum results in a prolifer...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Björklund, Lars M., Sánchez-Pernaute, Rosario, Chung, Sangmi, Andersson, Therese, Chen, Iris Yin Ching, McNaught, Kevin St. P., Brownell, Anna-Liisa, Jenkins, Bruce G., Wahlestedt, Claes, Kim, Kwang-Soo, Isacson, Ole
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2002
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122367/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11782534/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.022438099
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