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Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates

Dopamine (DA) loss in Parkinson’s disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN hyperactivity; however, the role of glutamate in alt...

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Principais autores: Arun Singh, Meagan A. Jenkins, Kenneth J. Burke, Jr., Goichi Beck, Andrew Jenkins, Annalisa Scimemi, Stephen F. Traynelis, Stella M. Papa
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2018-01-01
Serier:Cell Reports
Fag:
striatum
striatal projection neuron
SPN
medium spiny neuron
dopamine
glutamate
NMDAR
AMPAR
Parkinson’s disease
dyskinesia
Online adgang:http://www.sciencedirect.com/science/article/pii/S2211124717319320
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