Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates

Dopamine (DA) loss in Parkinson’s disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN hyperactivity; however, the role of glutamate in alt...

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Autors principals:	Arun Singh, Meagan A. Jenkins, Kenneth J. Burke, Jr., Goichi Beck, Andrew Jenkins, Annalisa Scimemi, Stephen F. Traynelis, Stella M. Papa
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2018-01-01
Col·lecció:	Cell Reports
Matèries:	striatum striatal projection neuron SPN medium spiny neuron dopamine glutamate NMDAR AMPAR Parkinson’s disease dyskinesia
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2211124717319320
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