Glutamatergic Tuning of Hyperactive Striatal Projection Neurons Controls the Motor Response to Dopamine Replacement in Parkinsonian Primates

Dopamine (DA) loss in Parkinson’s disease (PD) alters the function of striatal projection neurons (SPNs) and causes motor deficits, but DA replacement can induce further abnormalities. A key pathological change in animal models and patients is SPN hyperactivity; however, the role of glutamate in alt...

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Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Arun Singh, Meagan A. Jenkins, Kenneth J. Burke, Jr., Goichi Beck, Andrew Jenkins, Annalisa Scimemi, Stephen F. Traynelis, Stella M. Papa
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Elsevier 2018-01-01
Σειρά:	Cell Reports
Θέματα:	striatum striatal projection neuron SPN medium spiny neuron dopamine glutamate NMDAR AMPAR Parkinson’s disease dyskinesia
Διαθέσιμο Online:	http://www.sciencedirect.com/science/article/pii/S2211124717319320
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