Insulin-induced Drosophila S6 kinase activation requires phosphoinositide 3-kinase and protein kinase B.

An important mechanism by which insulin regulates cell growth and protein synthesis is through activation of the p70 ribosomal S6 protein kinase (S6K). In mammalian cells, insulin-induced PI3K (phosphoinositide 3-kinase) activation, generates the lipid second messenger PtdIns(3,4,5) P (3), which is...

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Bibliographic Details
Main Authors: Lizcano, Jose M, Alrubaie, Saif, Kieloch, Agnieszka, Deak, Maria, Leevers, Sally J, Alessi, Dario R
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223624/
https://ncbi.nlm.nih.gov/pubmed/12841848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030577
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