Cloning of an emopamil-binding protein (EBP)-like protein that lacks sterol delta8-delta7 isomerase activity.

EBP (emopamil-binding protein) is a high-affinity binding protein for [3H]emopamil and belongs to the family of so-called sigma receptors. Mutations that disrupt EBP's 3beta-hydroxysteroid sterol delta8-delta7 isomerase activity (EC 5.3.3.5) impair cholesterol biosynthesis and cause X-chromosom...

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Autores principales: Moebius, Fabian F, Fitzky, Barbara U, Wietzorrek, Georg, Haidekker, Alexander, Eder, Andrea, Glossmann, Hartmut
Formato: Artigo
Lenguaje:Inglês
Publicado: 2003
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223579/
https://ncbi.nlm.nih.gov/pubmed/12760743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030465
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