Low tetrahydrobiopterin biosynthetic capacity of human monocytes is caused by exon skipping in 6-pyruvoyl tetrahydropterin synthase.

Biosynthesis of (6 R )-5,6,7,8-tetrahydro-L-biopterin (H(4)-biopterin), an essential cofactor for aromatic amino acid hydroxylases and NO synthases, is effectively induced by cytokines in most of the cell types. However, human monocytes/macrophages form only a little H(4)-biopterin, but release neop...

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Detalhes bibliográficos
Main Authors: Leitner, Karin L, Meyer, Martina, Leimbacher, Walter, Peterbauer, Anja, Hofer, Susanne, Heufler, Christine, Müller, Angelika, Heller, Regine, Werner, Ernst R, Thöny, Beat, Werner-Felmayer, Gabriele
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223526/
https://ncbi.nlm.nih.gov/pubmed/12708971
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20030269
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