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Suppression of 6-pyruvoyl-tetrahydropterin synthase promotes remyelination in multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a CNS autoimmune disease that is characterized by demyelination, neuroinflammation, and neuronal loss. Although current chemotherapies and immunotherapies for MS efficiently mitigate disease activity and relief clinical symptoms, neuroprotection targeti...

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Principais autores: Hui Xiao, Ying Long, Yong-shun Guo, Yan-yan Zhu, Yue Wu, Yan-qing Yin, En-wei Ji, Gang Hu, Jun Gao, Jia-wei Zhou
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-11-01
Serier:BMC Medicine
Fag:
Oligodendrocyte precursor cells
Multiple sclerosis
6-Pyruvoyltetrahydropterin synthase
OPC proliferation
Remyelination
Online adgang:https://doi.org/10.1186/s12916-025-04351-0
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