Suppression of 6-pyruvoyl-tetrahydropterin synthase promotes remyelination in multiple sclerosis

Abstract Background Multiple sclerosis (MS) is a CNS autoimmune disease that is characterized by demyelination, neuroinflammation, and neuronal loss. Although current chemotherapies and immunotherapies for MS efficiently mitigate disease activity and relief clinical symptoms, neuroprotection targeti...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Hui Xiao, Ying Long, Yong-shun Guo, Yan-yan Zhu, Yue Wu, Yan-qing Yin, En-wei Ji, Gang Hu, Jun Gao, Jia-wei Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2025-11-01
coleção:	BMC Medicine
Assuntos:	Oligodendrocyte precursor cells Multiple sclerosis 6-Pyruvoyltetrahydropterin synthase OPC proliferation Remyelination
Acesso em linha:	https://doi.org/10.1186/s12916-025-04351-0
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!