Phosphatidylethanolamine N-methyltransferase (PEMT) knockout mice have hepatic steatosis and abnormal hepatic choline metabolite concentrations despite ingesting a recommended dietary intake of choline.

Choline is an essential nutrient for humans and is derived from the diet as well as from de novo synthesis involving methylation of phosphatidylethanolamine catalysed by the enzyme phosphatidylethanolamine N -methyltransferase (PEMT). This is the only known pathway that produces new choline molecule...

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Detalhes bibliográficos
Principais autores: Zhu, Xiaonan, Song, Jiannan, Mar, Mei-Heng, Edwards, Lloyd J, Zeisel, Steven H
Formato: Artigo
Idioma:Inglês
Publicado em: 2003
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223223/
https://ncbi.nlm.nih.gov/pubmed/12466019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021523
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