A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers.

Enhanced synthesis of a specific matrix metalloproteinase, MMP-2, has been demonstrated in experimental models of ventricular failure and in cardiac extracts from patients with ischaemic cardiomyopathy. Cultured neonatal rat cardiac fibroblasts and myocytes were used to analyse the determinants of M...

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Bibliographic Details
Main Authors: Bergman, Marina R, Cheng, Sunfa, Honbo, Norman, Piacentini, Lucia, Karliner, Joel S, Lovett, David H
Format: Artigo
Language:Inglês
Published: 2003
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223099/
https://ncbi.nlm.nih.gov/pubmed/12371906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020707
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