Factor VII mutant V154G models a zymogen-like form of factor VIIa.

Proteolytic cleavage of the peptide bond between Arg(152) and Ile(153) converts the procoagulant protein Factor VII (FVII) to an activated two-chain form (FVIIa). The formation of a salt bridge between Ile(153) and Asp(343) drives the conversion of FVIIa from being zymogen-like to the active form. I...

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Autors principals: Toso, Raffaella, Bernardi, Francesco, Tidd, Theresa, Pinotti, Mirko, Camire, Rodney M, Marchetti, Giovanna, High, Katherine A, Pollak, Eleanor S
Format: Artigo
Idioma:Inglês
Publicat: 2003
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223097/
https://ncbi.nlm.nih.gov/pubmed/12358603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020888
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