Protein kinase C- and calcium-regulated pathways independently synergize with Gi pathways in agonist-induced fibrinogen receptor activation.

Platelet fibrinogen receptor activation is a critical step in platelet plug formation. The fibrinogen receptor (integrin alphaIIbbeta3) is activated by agonist-mediated G(q) stimulation and resultant phospholipase C activation. We investigated the role of downstream signalling events from phospholip...

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Detalhes bibliográficos
Main Authors: Quinton, Todd M, Kim, Soochong, Dangelmaier, Carol, Dorsam, Robert T, Jin, Jianguo, Daniel, James L, Kunapuli, Satya P
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1223015/
https://ncbi.nlm.nih.gov/pubmed/12215172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020226
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