Substance P-stimulated interleukin-8 expression in human colonic epithelial cells involves Rho family small GTPases.

Interaction of the neuropeptide substance P (SP) and its neurokinin-1 receptor (NK-1R) plays an important role in the pathophysiology of intestinal inflammation. SP is known to stimulate production of interleukin (IL)-6 and IL-8 in the U-373-MG human astrocytoma cell line via activation of p38 MAPK...

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Detalhes bibliográficos
Main Authors: Zhao, Dezheng, Kuhnt-Moore, Sabina, Zeng, Huiyan, Pan, Amy, Wu, Jack S, Simeonidis, Simos, Moyer, Mary P, Pothoulakis, Charalabos
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222994/
https://ncbi.nlm.nih.gov/pubmed/12169092
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020950
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