Inhibition of telomerase by linear-chain fatty acids: a structural analysis.

In the present study, we have found that mono-unsaturated linear-chain fatty acids in the cis configuration with C(18) hydrocarbon chains (i.e. oleic acid) strongly inhibited the activity of human telomerase in a cell-free enzymic assay, with an IC(50) value of 8.6 microM. Interestingly, fatty acids...

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Detalhes bibliográficos
Main Authors: Oda, Masako, Ueno, Takamasa, Kasai, Nobuyuki, Takahashi, Hirotada, Yoshida, Hiromi, Sugawara, Fumio, Sakaguchi, Kengo, Hayashi, Hideya, Mizushina, Yoshiyuki
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222903/
https://ncbi.nlm.nih.gov/pubmed/12121150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20021089
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