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Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expression

A general strategy is described for forcing the engagement of an RNA/protein complex by using small-molecule ligands. A bivalent molecule was created by linking a protein-binding ligand to an RNA-binding ligand. On presentation of the chemical inducer of dimerization to the RNA by the protein, coope...

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Библиографические подробности
Главные авторы: Harvey, Isabelle, Garneau, Philippe, Pelletier, Jerry
Формат: Artigo
Язык:Inglês
Опубликовано: The National Academy of Sciences 2002
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC122288/
https://ncbi.nlm.nih.gov/pubmed/11854489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.042693399
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