Distinct sites for myotoxic and membrane-damaging activities in the C-terminal region of a Lys49-phospholipase A2.

Bothropstoxin-I (BthTx-I) is a Lys(49)-phospholipase A(2) from the venom of Bothrops jararacussu which demonstrates both myotoxic and Ca(2+)-independent membrane-damaging activities. The structural determinants of these activities are poorly defined, therefore site-directed mutagenesis has been used...

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Autores principales: Chioato, Lucimara, De Oliveira, Arthur H C, Ruller, Roberto, Sá, Juliana M, Ward, Richard J
Formato: Artigo
Lenguaje:Inglês
Publicado: 2002
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222840/
https://ncbi.nlm.nih.gov/pubmed/12079495
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020092
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