Topology of the substrate-binding site of a Lys(49)-phospholipase A(2) influences Ca(2+)-independent membrane-damaging activity

BthTx-I (bothropstoxin-I) is a myotoxic Lys(49)-PLA(2) (phospholipase A(2) with Lys(49)) isolated from Bothrops jararacussu venom, which damages liposome membranes by a Ca(2+)-independent mechanism. The highly conserved Phe(5)/Ala(102)/Phe(106) motif in the hydrophobic substrate-binding site of the...

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Autori principali: Sá, Juliana Martha, Chioato, Lucimara, Ferreira, Tatiana Lopes, de Oliveira, Arthur H. C., Ruller, Roberto, Rosa, José César, Greene, Lewis J., Ward, Richard J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Portland Press Ltd. 2004
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC1133930/
https://ncbi.nlm.nih.gov/pubmed/15147240
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20031946
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