Ubiquitin-dependent mechanism regulates rapid turnover of AU-rich cytokine mRNAs

An AU rich element (ARE) in the 3′ noncoding region promotes the rapid degradation of mammalian cytokine and proto-oncogene mRNAs, such as tumor necrosis factor-α, granulocyte–macrophage colony-stimulating factor (GM-CSF) and c-fos. Destabilization of ARE-mRNAs involves the association of ARE-bindin...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Laroia, Gaurav, Sarkar, Bedabrata, Schneider, Robert J.
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 2002
Matèries:	Biological Sciences
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC122281/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11842200/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.042575699
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