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Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.
Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 level...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2002
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1222650/ https://ncbi.nlm.nih.gov/pubmed/11950391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020340 |
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