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Activation of glucokinase gene expression by hepatic nuclear factor 4alpha in primary hepatocytes.

Glucokinase (GK) is a key enzyme for glucose utilization in liver and shows a higher expression in the perivenous zone. In primary rat hepatocytes, the GK gene expression was activated by HNF (hepatic nuclear factor)-4alpha via the sequence -52/-39 of the GK promoter. Venous pO2 enhanced HNF-4 level...

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Detalhes bibliográficos
Main Authors: Roth, Ulrike, Jungermann, Kurt, Kietzmann, Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222650/
https://ncbi.nlm.nih.gov/pubmed/11950391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20020340
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