Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.

We investigated the effects of two mutations in human cardiac troponin I, Arg(145)-->Gly and Gly(203)-->Ser, that are reported to cause familial hypertrophic cardiomyopathy. Mutant and wild-type troponin I, overexpressed in Escherichia coli, were used to reconstitute troponin complexes in vana...

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Hlavní autoři: Burton, David, Abdulrazzak, Hassan, Knott, Adam, Elliott, Kathryn, Redwood, Charles, Watkins, Hugh, Marston, Steven, Ashley, Chris
Médium: Artigo
Jazyk:Inglês
Vydáno: 2002
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222405/
https://ncbi.nlm.nih.gov/pubmed/11853553
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