A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.

Cyclo-oxygenase (COX) enzymes are the targets for non-steroidal anti-inflammatory drugs (NSAIDs). These drugs demonstrate a variety of inhibitory mechanisms, which include simple competitive, as well as slow binding and irreversible inhibition. In general, most NSAIDs inhibit COX-1 and -2 by similar...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Walker, M C, Kurumbail, R G, Kiefer, J R, Moreland, K T, Koboldt, C M, Isakson, P C, Seibert, K, Gierse, J K
Format: Artigo
Sprog:Inglês
Udgivet: 2001
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1222000/
https://ncbi.nlm.nih.gov/pubmed/11463341
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker