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The kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinase.

The substrate specificity of glycogen synthase kinase 3 (GSK3) is unusual in that efficient phosphorylation only occurs if another phosphoserine or phosphothreonine residue is already present four residues C-terminal to the site of GSK3 phosphorylation. One such substrate is the epsilon-subunit of r...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Päätekijät: Woods, Y L, Cohen, P, Becker, W, Jakes, R, Goedert, M, Wang, X, Proud, C G
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2001
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221774/
https://ncbi.nlm.nih.gov/pubmed/11311121
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