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Subnuclear distribution of topoisomerase I is linked to ongoing transcription and p53 status
The nonconserved, hydrophilic N-terminal domain of eukaryotic DNA topoisomerase I (topo I) is dispensable for catalytic activity in vitro but essential in vivo. There are at least five putative nuclear localization signals and a nucleolin-binding signal within the first 215 residues of the topo I N-...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The National Academy of Sciences
2002
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC122173/ https://ncbi.nlm.nih.gov/pubmed/11805286 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.022631899 |
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