Nitric oxide-dependent pro-oxidant and pro-apoptotic effect of metallothioneins in HL-60 cells challenged with cupric nitrilotriacetate.

Intracellular safeguarding functions of metallothioneins (MTs) include sequestering transition and heavy metals, scavenging free radicals and protecting against electrophiles. We report that MT protection against Cu-induced cytotoxicity can be reversed and pro-oxidant and pro-apoptotic effects can b...

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Detalhes bibliográficos
Main Authors: Liu, S, Kawai, K, Tyurin, V A, Tyurina, Y Y, Borisenko, G G, Fabisiak, J P, Quinn, P J, Pitt, B R, Kagan, V E
Formato: Artigo
Idioma:Inglês
Publicado em: 2001
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1221668/
https://ncbi.nlm.nih.gov/pubmed/11171119
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