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Mutations in the reduced-folate carrier affect protein localization and stability.

The reduced-folate-carrier (rfc) gene has been shown to be functionally important for reduced-folate transport in mammalian cells. In the present paper we describe the identification of alterations in both alleles of the rfc gene in a mutant Chinese-hamster ovary cell line deficient in methotrexate...

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Main Authors: Sadlish, H, Murray, R C, Williams, F M, Flintoff, W F
Format: Artigo
Jezik:Inglês
Izdano: 2000
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220880/
https://ncbi.nlm.nih.gov/pubmed/10677373
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