Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria.

Bax is a Bcl-2-family protein with pro-apoptotic activity that can form channels in lipid membranes. The protein has been shown to trigger cytochrome c release from mitochondria both in vitro and in vivo. Recombinant human Bax isolated in the presence of detergent was found to be present as an oligo...

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Bibliographic Details
Main Authors: Antonsson, B, Montessuit, S, Lauper, S, Eskes, R, Martinou, J C
Format: Artigo
Language:Inglês
Published: 2000
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220756/
https://ncbi.nlm.nih.gov/pubmed/10620504
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