Inhibition of gene expression by anti-sense C-5 propyne oligonucleotides detected by a reporter enzyme.

Using a reporter plasmid containing the luciferase gene under the control of the insulin-like growth factor 1 (IGF-1) promoter region [including its 5' untranslated region (UTR)], we demonstrate that a 17-mer oligophosphorothioate containing C-5 propyne pyrimidines is able to inhibit luciferase...

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Bibliographic Details
Main Authors: Hamel, Y, Lacoste, J, Frayssinet, C, Sarasin, A, Garestier, T, François, J C, Hélène, C
Format: Artigo
Language:Inglês
Published: 1999
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220189/
https://ncbi.nlm.nih.gov/pubmed/10215592
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