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Target site search and effective inhibition of leukaemic cell growth by a covalently closed multiple anti-sense oligonucleotide to c-myb.

Systematic secondary structure simulation of a target mRNA sequence is shown to be effective for locating a good anti-sense target site. Multiple selected anti-sense sequences were placed in a single molecule. The anti-sense oligonucleotide (oligo) was covalently closed to avoid exonuclease activiti...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Moon, I J, Lee, Y, Kwak, C S, Lee, J H, Choi, K, Schreiber, A D, Park, J G
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2000
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220853/
https://ncbi.nlm.nih.gov/pubmed/10677346
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