Sphingosine 1-phosphate stimulation of the p42/p44 mitogen-activated protein kinase pathway in airway smooth muscle. Role of endothelial differentiation gene 1, c-Src tyrosine kinase and phosphoinositide 3-kinase.

We report here that cultured airway smooth muscle cells contain transcripts of endothelial differentiation gene 1 (EDG-1), a prototypical orphan Gi-coupled receptor whose natural ligand is sphingosine 1-phosphate (S1P). This is consistent with data that showed that S1P activated both c-Src and p42/p...

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Hauptverfasser: Rakhit, S, Conway, A M, Tate, R, Bower, T, Pyne, N J, Pyne, S
Format: Artigo
Sprache:Inglês
Veröffentlicht: 1999
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC1220098/
https://ncbi.nlm.nih.gov/pubmed/10051434
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